提供RNA化學修飾、標記及分子偶聯服務，支援核酸穩定性調整、追蹤及遞送系統開發，適用於小分子RNA藥物相關研究。
服務特色
RNA化學修飾
依研究需求調整 RNA 修飾形式，以評估其穩定性與生物學特性。
標記服務
提供客製化標記，支援 RNA 追蹤及相關實驗分析。
分子偶聯
可評估小分子配體、抗體或其他分子之偶聯需求。
遞送研究支援
可配合 RNA 修飾、脂質體及其他遞送系統的研究規劃。
RNA修飾項目
| Modification Type | Modifications |
| Point Modification | 2’OME、dspacer、dI、rI、dU、2’F、2’MOE、LNA、m6A、m5C、m5U |
| End Modifications | Thiol、Amino Linker、Biotin、Phosphorylation、spacer C9、spacer C18 |
| Fluorescent Labeling | FAM、HEX、Cy3、Cy5、TET、VIC、TAMRA |
| Special Modifications | Cholesterol、GalNAc、DBCO、Desthiobiotin、Cy5.5、Cy7、Hexynyl、BHQ1、BHQ2、BHQ3、MGB、ATTO Series |
| Chimeric RNA | DNA\RNA RNA\2’F\2’OME\DNA |
| Dual-Labeling | FAM-BHQ1、FAM-TAMRA、FAM-Dab、TAMRA-BHQ2、CY3-BHQ2、CY5.5-BHQ3、CY7-BHQ3 |
小分子核酸藥物修飾項目
| Nucleic Acid Type | Chemical Modification and Fluorescent Labeling Services |
| siRNA | Sugar Modification: 2′-Ome , 2′-F, etc. Backbone Modification: PS (phosphorothioate) modification, etc. E nd modification: Chol (cholesterol), Biotin, Thiol, NH 2 , etc. Fluorescent labeling: Cy3, Cy5, etc. Customized chemical modification and fluorescent labeling proposal design |
| Antisense (ASO) | Sugar Modification: 2′-OMe, 2′-MOE, 2′-F, LNA, etc. Base Modification: methylated cytosine (5-Me-dC), etc. Backbone Modification: PS (phosphorothioate) modification, etc. E nd modification: Chol (cholesterol), etc. |
| Aptamer | Sugar Modification: 2′-OMe, 2′-NH2, 2′-F, LNA, etc. Base Modification: methylated cytosine (5-Me-dC), etc. Backbone Modification: PS (phosphorothioate) modification, etc. E nd modification: 3′-inverted thymidine, Chol (cholesterol), Biotin, Thiol, NH 2 , fluorescent dyes, etc. |
| Others | Custom chemical modification and fluorescent labeling services |
客製化遞送系統與偶聯服務
| Delivery System | Features | Services |
| GalNAc (N-acetylgalactosamine) | GalNAc is the targeting ligand of the sialic acid receptor (ASGPR), which is mainly expressed on the surface of hepatic parenchymal cells. The conjugate of nucleic acid and GalNAc enters the cell through endocytosis to function. | Custom GalNAc Synthesis GalNAc-siRNA Synthesis GalNAc-ASO Synthesis GalNAc-miRNA Synthesis Customized design and synthesis of GalNAc delivery proposal |
| Peptide | Peptides have better membrane permeability and strong resistance to degradation. Therefore, conjugating oligonucleotides with various biological functions to peptides can not only improve the biological activity of oligonucleotides but also enhance their cell permeability. | Peptide Synthesis (drug peptides, custom peptides, RGD cyclic peptides, etc.) Peptide-siRNA Conjugation Peptide-ASO Conjugation Peptide-DNA Conjugation RGD-siRNA Conjugation |
| Lipid | LNP not only prevents degradation of delivered oligonucleotides and prolongs circulation time, but also facilitates oligonucleotide uptake, enhances intracellular transport, and facilitates endosomal escape. | LNP-siRNA Conjugation LNP-ASO Conjugation |
| PEG (polyethylene glycol) | The half-life of PEG-modified ASO in the body is significantly prolonged, and PEG can reduce the excretion rate of oligonucleotides and promote the uptake of nucleic acid drugs by corresponding cells. | PEG-Aptamer Conjugation PEG-siRNA Conjugation PEG-ASO Conjugation |
| Others | / | Custom delivery proposal design and synthesis |
聯絡資訊
E-mail : [email protected]
Line ID : @abreal